A 42-day feeding trial evaluated the effects of sunflower seed meal (SFSM) inclusion and Ronoxyme® HiPhos enzyme supplementation on the growth performance and economic returns of weaner and grower rabbits. Using a 3×3 factorial arrangement in a completely randomized design, 72 rabbits were allotted to nine isocaloric (2500 kcal/kg ME) and isonitrogenous (15% CP) diets containing 0%, 10%, or 20% SFSM with 0, 150, or 250 ppm enzyme. During the weaner phase, average daily feed, protein, and energy intakes differed significantly (P<0.05) among SFSM levels, with 20% SFSM producing the highest values. Enzyme supplementation at 250 ppm significantly increased protein intake compared to unsupplemented diets. However, no significant interactions (P > 0.05) were observed between SFSM level and enzyme inclusion for growth traits. In the grower phase, rabbits fed 10% and 20% SFSM exhibited higher average daily weight gain and protein efficiency ratios than those on the 0% SFSM diet. Economic analysis revealed that 20% SFSM, particularly when supplemented with enzymes, yielded superior weight gain, revenue, and net income, alongside a reduced feed conversion ratio and lower production cost per kilogram of weight gain. Overall, incorporating SFSM up to 20% improved growth performance and profitability of rabbit production, with enzyme supplementation providing additional nutritional benefits.